Description

n-Boc-L-Valine-o-Nitrophenyl Ester is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is specifically designed to facilitate the controlled coupling of L-valine residues under mild conditions, ensuring high coupling efficiency and minimal racemization. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical coupling reagent for the sequential addition of Boc-protected L-valine in automated and manual peptide synthesis.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methods for constructing complex peptide sequences and natural products.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for peptide drugs, including hormones and enzyme inhibitors.
• Bioconjugation: Employed to attach valine or peptide motifs to other molecules, such as proteins, polymers, or surfaces, for creating targeted drug delivery systems or diagnostic probes.
• Research & Development: A staple reagent in academic and industrial R&D labs for exploring new peptide structures, studying structure-activity relationships (SAR), and developing novel bioactive compounds.
• Production of Protected Dipeptides & Oligopeptides: Used to efficiently synthesize short peptide fragments with precise stereochemistry for further chemical elaboration.

Basic Information

Item	Detail
Product Name	n-Boc-L-Valine-o-Nitrophenyl Ester
CAS No.	41120-72-3
Molecular Formula	C₁₆H₂₂N₂O₆
Molecular Weight	338.36 g/mol
Synonyms	Boc-Val-ONp; N-(tert-Butoxycarbonyl)-L-valine 4-nitrophenyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid 4-nitrophenyl ester; tert-Butyloxycarbonyl-L-valine p-nitrophenyl ester; Boc-L-Val-ONp; Boc-Valine p-nitrophenyl ester; N-Boc-L-valine 4-nitrophenyl ester; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-L-Valine-o-Nitrophenyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.