Description

1,3-Dihydro-4-[4-(Phenylthio)Phenyl]-2H-1,5-Benzodiazepine-2-Thione is a specialized organic compound belonging to the benzodiazepine-thione class, serving as a key advanced intermediate in pharmaceutical research and development. Its unique molecular structure, featuring a phenylthio substituent, makes it a valuable building block for synthesizing novel therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disorder drug discovery. This high-purity intermediate is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel benzodiazepine-derived active pharmaceutical ingredients (APIs) for therapeutic applications.
• Medicinal Chemistry Research: Used as a scaffold or building block in drug discovery programs targeting CNS disorders, anxiety, and other neurological conditions.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for new chemical entities (NCEs) during pre-clinical and clinical stages.
• Biochemical Tool Compound: Potential use in biochemical assays and pharmacological studies to investigate specific receptor interactions or enzyme activities.
• Fine Chemical Synthesis: Serves as a specialized intermediate for constructing complex heterocyclic compounds in advanced organic synthesis.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions.

Basic Information

Product Name	1,3-Dihydro-4-[4-(Phenylthio)Phenyl]-2H-1,5-Benzodiazepine-2-Thione
CAS No.	41054-49-3
Molecular Formula	C21H16N2S2
Molecular Weight	360.50 g/mol
Synonyms	4-[4-(Phenylthio)phenyl]-1,3-dihydro-2H-1,5-benzodiazepine-2-thione; 4-(4-Phenylsulfanylphenyl)-1,5-benzodiazepine-2-thione; 1,5-Benzodiazepine-2-thione, 1,3-dihydro-4-[4-(phenylthio)phenyl]-; 4-(4-(Phenylthio)phenyl)-2H-1,5-benzodiazepine-2-thione; Benzodiazepine Thione Intermediate; CAS 41054-49-3; 41054-49-3
EINECS	Contact for details

Quality Control

Our 1,3-Dihydro-4-[4-(Phenylthio)Phenyl]-2H-1,5-Benzodiazepine-2-Thione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.