Description

2,4-Bis[(Trimethylsilyl)Oxy]Pyridine is a specialized organosilicon-protected derivative of pyridine, serving as a crucial synthetic intermediate and protecting group reagent. Its primary value lies in its ability to protect sensitive hydroxyl groups during complex multi-step organic synthesis, particularly in the production of pharmaceuticals and advanced materials. This compound is essential for R&D chemists and process development scientists working in pharmaceutical, agrochemical, and fine chemical manufacturing who require high-purity, reliable building blocks for sensitive reactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for nucleoside analogs and other heterocyclic compounds.
• Protecting Group Reagent: Used to temporarily protect hydroxyl groups in complex multi-step organic syntheses, preventing unwanted side reactions.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Precursor for creating functionalized silicon-containing polymers and advanced organic electronic materials.
• Academic & Industrial R&D: Valuable reagent for method development and exploring new synthetic pathways in medicinal and process chemistry.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring selective protection strategies.

Basic Information

Product Name	2,4-Bis[(Trimethylsilyl)Oxy]Pyridine
CAS No.	40982-58-9
Molecular Formula	C11H21NO2Si2
Molecular Weight	255.46 g/mol
Synonyms	2,4-Bis(trimethylsiloxy)pyridine; Pyridine, 2,4-bis[(trimethylsilyl)oxy]-; 2,4-Di-O-trimethylsilylpyridine; 2,4-Bis(trimethylsilyloxy)pyridine; 2,4-Pyridinediol, bis(trimethylsilyl) ether; TMS-protected 2,4-dihydroxypyridine; 40982-58-9
EINECS	Contact for details

Quality Control

Our 2,4-Bis[(Trimethylsilyl)Oxy]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.