Description

3-Benzofurancarboxylic Acid, 5-Methoxy-2-(1-Piperidinylmethyl)-, Ethyl Ester, Hydrochloride (1:1) is a high-purity, complex organic intermediate of significant interest in advanced pharmaceutical synthesis. This compound, with CAS number 40963-83-5, is valued for its specific benzofuran-piperidine hybrid structure, which is a key pharmacophore in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of potential drug candidates targeting central nervous system (CNS) disorders, inflammation, or other therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Intermediate in the synthesis of novel crop protection agents, leveraging its heterocyclic structure.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular probes to study biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for advanced intermediates under GMP-like conditions.

Basic Information

Product Name	3-Benzofurancarboxylic Acid, 5-Methoxy-2-(1-Piperidinylmethyl)-, Ethyl Ester, Hydrochloride (1:1)
CAS No.	40963-83-5
Molecular Formula	C18H25NO4 • HCl
Molecular Weight	355.86 g/mol (Free base: 319.40 g/mol)
Synonyms	5-Methoxy-2-(piperidin-1-ylmethyl)benzofuran-3-carboxylic acid ethyl ester hydrochloride; Ethyl 5-methoxy-2-(piperidin-1-ylmethyl)-1-benzofuran-3-carboxylate hydrochloride; 2-(1-Piperidinylmethyl)-5-methoxy-3-benzofurancarboxylic Acid Ethyl Ester Hydrochloride; 40963-83-5; UNII-7Q6I4555J2; 7Q6I4555J2; SCHEMBL2180225; DTXSID60672969
EINECS	Contact for details

Quality Control

Our 3-Benzofurancarboxylic Acid, 5-Methoxy-2-(1-Piperidinylmethyl)-, Ethyl Ester, Hydrochloride (1:1) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.