Description

2-Chloroethyl Trifluoroacetate is a versatile fluorinated building block and reagent in advanced organic synthesis. Its value lies in the trifluoroacetyl group, a key moiety for introducing fluorine atoms to enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and prodrugs.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science: Serves as a monomer or modifier in the production of specialty polymers and coatings with unique chemical resistance.
• Organic Synthesis Reagent: Employed as a trifluoroacetylating agent for alcohols and amines in complex molecule construction.
• Liquid Crystal & OLED Material Precursor: Used in the synthesis of fluorinated components for electronic displays and devices.
• Cross-coupling Reactions: Acts as an electrophile in palladium-catalyzed reactions to form carbon-carbon bonds.

Basic Information

Product Name	2-Chloroethyl Trifluoroacetate
CAS No.	40949-99-3
Molecular Formula	C4H4ClF3O2
Molecular Weight	176.52 g/mol
Synonyms	2-Chloroethyl Trifluoroacetate; Trifluoroacetic Acid 2-Chloroethyl Ester; 2-Chloroethyl 2,2,2-Trifluoroacetate; 2-Chloroethanol Trifluoroacetate; β-Chloroethyl Trifluoroacetate; Ethanol, 2-chloro-, 1,1,1-trifluoroacetate; 40949-99-3; CF3COOCH2CH2Cl
EINECS	Contact for details

Quality Control

Our 2-Chloroethyl Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The product is moisture-sensitive; keep container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.42 g/mL
Refractive Index (n20D)	~1.365

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.