Description

α-Lipoic Acid-Nhs is a high-purity, activated ester derivative of the essential cofactor α-lipoic acid, specifically designed for bioconjugation and peptide synthesis. This compound matters for its role as a critical linker molecule, enabling the stable and efficient attachment of lipoic acid moieties to proteins, antibodies, and other biomolecules for research and diagnostic applications. It is primarily needed by manufacturers and research institutions in the pharmaceutical, biotechnology, and life science sectors developing advanced therapeutic conjugates, diagnostic assays, and labeled probes.

Application

• Bioconjugation Reagent: Used for the covalent attachment of α-lipoic acid to amines on proteins, peptides, and antibodies.
• Surface Functionalization: Key for modifying gold nanoparticles, biosensor chips, and other surfaces with lipoic acid for subsequent binding studies.
• Diagnostic Kit Manufacturing: Employed in the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays.
• Drug Delivery Systems: Serves as a linker in the development of antibody-drug conjugates (ADCs) and targeted nanoparticle therapies.
• Biomolecular Labeling: Facilitates the site-specific labeling of biomolecules with tags, fluorophores, or other functional groups.
• Research & Development: Essential tool in academic and industrial R&D for studying protein interactions, cellular uptake, and molecular imaging.

Basic Information

Product Name	α-Lipoic Acid-Nhs
CAS No.	40846-94-4
Molecular Formula	C14H19NO5S2
Molecular Weight	345.44 g/mol
Synonyms	1,2-Dithiolane-3-pentanoic Acid, N-Hydroxysuccinimide Ester; 5-(1,2-Dithiolan-3-yl)pentanoic Acid N-Succinimidyl Ester; (±)-α-Lipoic Acid N-Hydroxysuccinimide Ester; (±)-Thioctic Acid NHS Ester; ALA-NHS; Lipoic Acid NHS Ester; 6,8-Thioctic Acid NHS Ester; DL-α-Lipoic Acid N-Hydroxysuccinimide Ester
EINECS	Contact for details

Quality Control

Our α-Lipoic Acid-Nhs is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with full batch traceability are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.