Description

Methyl 2-Isocyano-3-Methylbutyrate is a versatile isocyanide ester building block used in organic synthesis. Its primary value lies in its role as a key precursor in multicomponent reactions, such as the Ugi and Passerini reactions, enabling the efficient construction of complex heterocycles and peptidomimetics. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel molecular scaffolds.

Application

• Pharmaceutical Intermediates: A critical building block for synthesizing novel drug candidates, particularly peptidomimetics and heterocyclic compounds.
• Agrochemical Synthesis: Used in the development of new active ingredients for crop protection products.
• Multicomponent Reaction (MCR) Chemistry: A key reactant in Ugi, Passerini, and related isocyanide-based reactions for rapid library generation.
• Peptide & Protein Mimetics: Facilitates the creation of stable, bioavailable peptide analogs for therapeutic applications.
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic materials.
• Chemical Biology Probes: Serves as a precursor for labeling reagents and activity-based probes used in biochemical research.

Basic Information

Product Name	Methyl 2-Isocyano-3-Methylbutyrate
CAS No.	40846-66-0
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	2-Isocyano-3-methylbutyric acid methyl ester; Methyl 2-isocyano-3-methylbutanoate; 3-Methyl-2-isocyanobutanoic acid methyl ester; Methyl α-isocyanovalerate; Methyl 2-isocyanovalerate; Isocyanide C7; Methyl ester of 2-isocyano-3-methylbutyric acid
EINECS	Contact for details

Quality Control

Our Methyl 2-Isocyano-3-Methylbutyrate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat, sparks, and open flame. Due to its sensitivity, minimize exposure to air and moisture during handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.