Description

3β,16β-Bis(Trimethylsiloxy)Androst-5-En-17-One CAS NO 40822-67-1 is a high-purity, protected steroid intermediate, specifically a silyl ether derivative of androstenedione. This compound is critical for pharmaceutical research and development, serving as a key building block in the synthesis of more complex steroid-based active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the targeted modification of steroid scaffolds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel steroid-based therapeutics, including potential anti-inflammatory, hormonal, and anticancer agents.
• Steroid Chemistry Research: Used in academic and industrial laboratories to study steroid metabolism, receptor interactions, and structure-activity relationships (SAR).
• Process Chemistry Development: Employed in the development and scale-up of efficient synthetic routes for complex steroid molecules under GMP or non-GMP conditions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in steroid analysis.
• Fine Chemical Synthesis: Used as a specialized building block for creating custom steroid derivatives and analogs for various research applications.

Basic Information

Product Name	3β,16β-Bis(Trimethylsiloxy)Androst-5-En-17-One
CAS No.	40822-67-1
Molecular Formula	C25H44O3Si2
Molecular Weight	448.80 g/mol
Synonyms	3β,16β-Bis(trimethylsilyloxy)androst-5-en-17-one; Androst-5-ene-17-one, 3,16-bis[(trimethylsilyl)oxy]-, (3β,16β)-; 3β,16β-Di-O-trimethylsilylandrost-5-en-17-one; 3,16-Bis-O-(trimethylsilyl)androst-5-en-17-one; Protected Androstenedione Derivative; Silylated Androstene Intermediate; TMS Ether of 3β,16β-Dihydroxyandrost-5-en-17-one
EINECS	Contact for details

Quality Control

Our 3β,16β-Bis(Trimethylsiloxy)Androst-5-En-17-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.