Description

5-Chloropyridine-2-Thiol is a versatile sulfur-containing heterocyclic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a chlorine substituent and a thiol group on the pyridine ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides with specific modes of action.
• Ligand and Catalyst Development: Serves as a building block for creating chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of functional polymers and organic electronic materials.
• Chemical Biology Probes: Useful for synthesizing probes that study enzyme mechanisms or protein interactions via its reactive thiol group.

Basic Information

Product Name	5-Chloropyridine-2-Thiol
CAS No.	40771-41-3
Molecular Formula	C5H4ClNS
Molecular Weight	145.61 g/mol
Synonyms	2-Mercapto-5-chloropyridine; 5-Chloro-2-pyridinethiol; 5-Chloro-2-mercaptopyridine; 2-Pyridinethiol, 5-chloro-; 5-Chloro-2-thiopyridinol; 5-Chloro-2-sulfanylpyridine; 5-Chloro-2-pyridyl mercaptan; 5-Chloro-2-thiolpyridine
EINECS	Contact for details

Quality Control

Our 5-Chloropyridine-2-Thiol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C to minimize oxidation and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.