Description

4'-Demethylpodophyllotoxin is a key intermediate and a natural lignan derivative with significant biological activity. This compound is valued for its role as a versatile precursor in the synthesis of potent chemotherapeutic agents and other bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in anticancer drug discovery and development.

Application

• Pharmaceutical Intermediate: Critical precursor for the semi-synthesis of anticancer drugs such as etoposide, teniposide, and etopophos.
• Biochemical Research: Used as a reference standard and active compound in studies targeting topoisomerase II inhibition and apoptosis.
• Lead Compound Development: Serves as a structural scaffold for medicinal chemistry programs aimed at developing novel cytotoxic agents.
• Natural Product Isolation Standard: Employed in analytical methods for the identification and quantification of podophyllotoxin derivatives in plant extracts.

Basic Information

Product Name	4'-Demethylpodophyllotoxin
CAS No.	40505-27-9
Molecular Formula	C21H20O8
Molecular Weight	400.38 g/mol
Synonyms	4'-Demethylpodophyllotoxin; 4'-Desmethylpodophyllotoxin; NSC 334012; Podophyllotoxin, 4'-demethyl-; 5,8,8a,9-Tetrahydro-9-hydroxy-10-methoxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
EINECS	Contact for details

Quality Control

Our 4'-Demethylpodophyllotoxin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR). We provide Certificates of Analysis (COA) with detailed results for all critical parameters, ensuring traceability and compliance with research and cGMP-grade material expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.