Description

trans-Ethyl 2-(Hydroxymethyl)-Cyclopropanecarboxylate is a versatile chiral cyclopropane derivative, a key building block in advanced organic synthesis. Its value lies in the combination of a reactive ester group and a protected hydroxymethyl functionality on the strained cyclopropane ring, enabling precise stereochemical control in complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), including potential antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the cyclopropane moiety often contributes to biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Building Block: Employed in the research and production of complex fragrances, flavors, and specialty materials requiring specific stereochemistry.
• Material Science Research: Investigated for the synthesis of monomers and polymers with unique structural and physical properties derived from the rigid cyclopropane ring.

Basic Information

Product Name	trans-Ethyl 2-(Hydroxymethyl)-Cyclopropanecarboxylate
CAS No.	40427-14-3
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	Ethyl (1R,2S)-2-(Hydroxymethyl)cyclopropanecarboxylate; Ethyl trans-2-(Hydroxymethyl)cyclopropanecarboxylate; (1R,2S)-2-(Hydroxymethyl)cyclopropanecarboxylic Acid Ethyl Ester; trans-2-(Hydroxymethyl)cyclopropanecarboxylic Acid Ethyl Ester; 2-(Hydroxymethyl)cyclopropanecarboxylic Acid Ethyl Ester, trans-; Cyclopropanecarboxylic acid, 2-(hydroxymethyl)-, ethyl ester, (1R,2S)-rel-
EINECS	Contact for details

Quality Control

Our trans-Ethyl 2-(Hydroxymethyl)-Cyclopropanecarboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.