Description

Z-Pyr-Osu CAS NO 40291-26-7 is a specialized active ester reagent widely used in peptide synthesis and bioconjugation chemistry. This compound serves as a critical building block for forming amide bonds under mild conditions, enabling the efficient and selective modification of biomolecules. It is an essential tool for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing novel therapeutics, diagnostic agents, and advanced materials.

Application

• Peptide Synthesis: As a coupling reagent for the efficient formation of peptide bonds in solid-phase and solution-phase synthesis.
• Antibody-Drug Conjugates (ADCs): For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies, a key technology in targeted cancer therapy.
• Protein Labeling & Modification: Enables the attachment of fluorescent dyes, affinity tags (e.g., biotin), or polyethylene glycol (PEG) chains to proteins for research, diagnostics, and therapeutic applications.
• Biomaterial Functionalization: Used to modify surfaces (e.g., nanoparticles, hydrogels, chips) with bioactive peptides or proteins to create advanced cell culture substrates and biosensors.
• Small Molecule Prodrug Development: Facilitates the creation of cleavable linkers for prodrug strategies, improving drug solubility and targeted delivery.
• Crosslinking Agent: For creating stable crosslinks between amine-containing molecules in the study of protein-protein interactions or material science.

Basic Information

Product Name	Z-Pyr-Osu
CAS No.	40291-26-7
Molecular Formula	C19H18N2O7
Molecular Weight	386.36 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-L-proline N-hydroxysuccinimide ester; Z-L-Proline N-succinimidyl ester; Z-Pro-OSu; Z-Proline-OSu; Cbz-Pro-OSu; N-Cbz-L-Proline N-hydroxysuccinimide ester; Nα-Carbobenzoxy-L-proline N-succinimidyl ester; NSC 334381
EINECS	Contact for details

Quality Control

Our Z-Pyr-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-55° to -65° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.