Description

3β,6β-Bis[(Trimethylsilyl)Oxy]-5α-Cholestane CAS NO 40272-80-8 is a high-purity, organosilicon-protected derivative of cholestane, a key steroid backbone. This compound serves as a critical synthetic intermediate and analytical reference standard in advanced organic and medicinal chemistry research. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the synthesis and study of steroidal compounds, hormones, and related bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroidal drugs and novel therapeutic agents.
• Reference Standard: Used for analytical method development, validation, and quality control in HPLC, GC-MS, and NMR for sterol analysis.
• Chemical Research: Serves as a protected precursor in organic synthesis, enabling specific functional group manipulations on the steroidal core.
• Biochemical Studies: Employed in metabolic pathway research and as a probe for studying enzyme interactions with sterol substrates.
• Material Science: Potential precursor for creating specialized sterol-based liquid crystals or surface-modifying agents.

Basic Information

Product Name	3β,6β-Bis[(Trimethylsilyl)Oxy]-5α-Cholestane
CAS No.	40272-80-8
Molecular Formula	C33H62O2Si2
Molecular Weight	546.99 g/mol
Synonyms	5α-Cholestane-3β,6β-diol, 3β,6β-bis(trimethylsilyl) ether; 3β,6β-Bis(trimethylsiloxy)-5α-cholestane; Cholestane-3β,6β-diol bis(trimethylsilyl ether); 5α-Cholestane-3β,6β-diyl bis(trimethylsilyl) ether; 3β,6β-Di-O-trimethylsilyl-5α-cholestane; TMS derivative of 5α-cholestane-3β,6β-diol
EINECS	Contact for details

Quality Control

Our 3β,6β-Bis[(Trimethylsilyl)Oxy]-5α-Cholestane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and spectroscopic identification (NMR, IR, MS) to ensure structural integrity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent hydrolysis of the silyl ether groups. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.