Description

((3-Methoxyphenyl)Ethynyl)-Trimethylsilane is a specialized organosilicon building block featuring a terminal alkyne protected by a trimethylsilyl (TMS) group. This compound is valued for its role in facilitating controlled carbon-carbon bond formation, particularly in Sonogashira and other cross-coupling reactions. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex organic molecules and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing alkynyl-substituted aromatic scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides that require specific arylacetylene structures.
• Material Science: Serves as a monomer or cross-linking agent in the production of conjugated polymers and organic semiconductors for electronic devices.
• Chemical Research: Employed in academic and industrial R&D for palladium-catalyzed coupling reactions to create new molecular libraries.
• Ligand & Catalyst Development: Useful for synthesizing specialized alkynyl ligands for metal complexes.
• Fine Chemical Production: Integral in the multi-step synthesis of dyes, flavors, and fragrances.

Basic Information

Product Name	((3-Methoxyphenyl)Ethynyl)-Trimethylsilane
CAS No.	40230-92-0
Molecular Formula	C12H16OSi
Molecular Weight	204.34 g/mol
Synonyms	1-((3-Methoxyphenyl)ethynyl)-1,1,1-trimethylsilane; Trimethyl((3-methoxyphenyl)ethynyl)silane; 3-((Trimethylsilyl)ethynyl)anisole; m-Methoxyphenylacetylene trimethylsilyl derivative; TMS-protected 3-ethynylanisole; (3-Methoxyphenylethynyl)trimethylsilane; Silane, trimethyl[(3-methoxyphenyl)ethynyl]-
EINECS	Contact for details

Quality Control

Our production of ((3-Methoxyphenyl)Ethynyl)-Trimethylsilane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is analyzed via GC, HPLC, and NMR to confirm identity and purity, with all critical parameters documented. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing assay results and impurity profiles to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and highly volatile; ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.