Description

2-(Trimethylsilylethynyl)Anisole is a high-purity organosilicon building block featuring a trimethylsilyl-protected alkyne group ortho to a methoxy substituent on a benzene ring. This compound is valued for its role as a versatile synthetic intermediate in advanced organic synthesis, particularly in cross-coupling and cycloaddition reactions. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially those requiring Sonogashira or other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the protected alkyne moiety is incorporated into the active structure.
• Material Science & OLED Development: Serves as a precursor for creating conjugated organic semiconductors, dendrimers, and light-emitting materials for electronic devices.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry, including studies on cycloadditions and new catalytic systems.
• Ligand and Catalyst Preparation: Used to synthesize sophisticated ligand frameworks for asymmetric catalysis and metal-organic complexes.

Basic Information

Product Name	2-(Trimethylsilylethynyl)Anisole
CAS No.	40230-91-9
Molecular Formula	C12H16OSi
Molecular Weight	204.34 g/mol
Synonyms	2-[(Trimethylsilyl)ethynyl]anisole; 1-Methoxy-2-[(trimethylsilyl)ethynyl]benzene; Anisole, 2-(trimethylsilylethynyl)-; 2-(Trimethylsilylethynyl)methoxybenzene; o-(Trimethylsilylethynyl)anisole; 2-Ethynylanisole, trimethylsilyl derivative; Benzene, 1-methoxy-2-[(trimethylsilyl)ethynyl]-
EINECS	Contact for details

Quality Control

Every batch of 2-(Trimethylsilylethynyl)Anisole is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. Our standard grade meets a minimum purity specification of 98% (typically by GC or HPLC). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.