Description

(S)-2-[(tert-Butoxycarbonyl)Amino]-3-Methylbutanoic Acid Chloromethyl Ester is a high-purity, chiral building block essential for advanced organic synthesis. This Boc-protected amino acid derivative is a critical intermediate for the preparation of peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Serves as a protected amino acid component in solid-phase and solution-phase peptide coupling reactions.
• Prodrug Development: Used in the design and synthesis of chloromethyl ester prodrugs to enhance drug bioavailability.
• Chemical Biology Research: Employed in the creation of labeled probes and molecular tools for studying enzyme mechanisms.
• Asymmetric Synthesis: A valuable starting material for constructing complex, stereodefined natural product analogs.
• API Manufacturing: Integral in the multi-step synthesis of chiral active pharmaceutical ingredients requiring high enantiomeric purity.

Basic Information

Product Name	(S)-2-[(tert-Butoxycarbonyl)Amino]-3-Methylbutanoic Acid Chloromethyl Ester
CAS No.	40224-39-3
Molecular Formula	C11H20ClNO4
Molecular Weight	265.73 g/mol
Synonyms	Boc-L-Valine chloromethyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid chloromethyl ester; Boc-Val-OMe-Cl; Chloromethyl (S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanoate; Boc-L-Valine, chloromethyl ester; N-(tert-Butoxycarbonyl)-L-valine chloromethyl ester; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, chloromethyl ester
EINECS	Contact for details

Quality Control

Our (S)-2-[(tert-Butoxycarbonyl)Amino]-3-Methylbutanoic Acid Chloromethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for pharmaceutical research. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP guidelines for the production of advanced intermediates, ensuring reliable supply and traceability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to minimize moisture uptake and degradation. Handle and store away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.