Description

(S)-2-Isocyanato-3-Phenylpropionic Acid Methyl Ester CAS NO 40203-94-9 is a chiral, enantiomerically pure building block of significant value in asymmetric synthesis. This compound is a versatile intermediate, prized for its reactive isocyanate group and ester functionality, enabling its use in the construction of complex, biologically active molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme modulators, and other pharmacologically active compounds requiring high stereochemical purity.
• Agrochemical Synthesis: Used in the research and production of advanced, enantiomerically pure pesticides and herbicides.
• Peptide Mimetics & Urethane Chemistry: The reactive isocyanate group facilitates the formation of urethane linkages, making it valuable for creating peptide analogs and specialty polymers.
• Asymmetric Catalysis Research: Serves as a standard or reagent in methodological studies for developing new asymmetric transformations.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring chiral complexity.
• Material Science: Potential use in the synthesis of specialized monomers for high-performance polymers and coatings.

Basic Information

Product Name	(S)-2-Isocyanato-3-Phenylpropionic Acid Methyl Ester
CAS No.	40203-94-9
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	(S)-Methyl 2-Isocyanato-3-phenylpropanoate; (S)-Methyl 2-Isocyanato-3-phenylpropionate; L-2-Isocyanato-3-phenylpropionic Acid Methyl Ester; Methyl (S)-2-isocyanato-3-phenylpropanoate; (S)-2-Isocyanato-3-phenylpropanoic Acid Methyl Ester; NSC 334906; Methyl (αS)-α-isocyanatobenzenepropanoate
EINECS	Contact for details

Quality Control

Our production of (S)-2-Isocyanato-3-Phenylpropionic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for advanced synthetic applications. Each lot is characterized by comprehensive analytical methods including chiral HPLC, NMR, and IR spectroscopy. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dedicated, well-ventilated freezer. Due to its highly volatile and easily oxidized nature, prolonged exposure to air, moisture, or elevated temperatures must be avoided to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.