Description

Diethyl [[[3-(2,6-Dimethyl-4-Pyridyl)Phenyl]Amino]Methylene]Malonate is a high-purity, advanced pharmaceutical intermediate characterized by its specific malonate ester and substituted pyridyl-phenylamine structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic frameworks. Pharmaceutical R&D and fine chemical manufacturers need this material for developing next-generation drug candidates, where consistent quality and reliable supply are paramount for successful scale-up and regulatory approval.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug molecules, especially those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Chemical Synthesis Building Block: Used in organic synthesis for constructing complex heterocyclic systems via cyclization and condensation reactions, leveraging its reactive methylene malonate group.
• Research & Development (R&D): Essential for medicinal chemistry research in academic and industrial laboratories for exploring new chemical entities and structure-activity relationships (SAR).
• Agrochemical Intermediate: Potential application in the development of advanced crop protection agents that require specific pyridine-based scaffolds.
• Material Science Precursor: Can be utilized in the synthesis of specialized organic ligands and functional molecules for advanced materials.

Basic Information

Product Name	Diethyl [[[3-(2,6-Dimethyl-4-Pyridyl)Phenyl]Amino]Methylene]Malonate
CAS No.	40034-52-4
Molecular Formula	C21H24N2O4
Molecular Weight	368.43 g/mol
Synonyms	Diethyl (3-((2,6-dimethylpyridin-4-yl)phenylamino)methylene)malonate; Diethyl [[(3-(2,6-Dimethyl-4-pyridinyl)phenyl)amino]methylene]propanedioate; Propanedioic acid, [[[3-(2,6-dimethyl-4-pyridinyl)phenyl]amino]methylene]-, diethyl ester; Diethyl (Z)-2-((3-(2,6-dimethylpyridin-4-yl)phenylamino)methylene)malonate; (E)-Diethyl 2-((3-(2,6-dimethylpyridin-4-yl)phenylamino)methylene)malonate; Malonic acid, [(3-(2,6-dimethyl-4-pyridyl)anilino)methylene]-, diethyl ester
EINECS	Contact for details

Quality Control

Our Diethyl [[[3-(2,6-Dimethyl-4-Pyridyl)Phenyl]Amino]Methylene]Malonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.