Description

4-(Isocyanomethyl)Benzyl-Isocyanide is a versatile bifunctional isocyanide building block, a key intermediate in advanced organic synthesis. Its dual isocyanide functionality enables efficient construction of complex heterocyclic and macrocyclic structures, which is critical for developing novel materials and bioactive compounds. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, agrochemical discovery, and materials science who require reliable, high-quality building blocks for their synthetic pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for constructing complex heterocyclic cores via multicomponent reactions (MCRs) like the Ugi and Passerini reactions.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, where its reactive groups allow for the creation of diverse molecular scaffolds with potential biological activity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized isocyanide-based ligands used in transition metal catalysis and organocatalysis.
• Polymer and Material Science: Employed in the synthesis of functional polymers, dendrimers, and smart materials that require precise molecular architecture.
• Chemical Biology & Proteomics: Utilized in bio-conjugation strategies and as a tool compound for probing biological systems and developing activity-based probes.
• Combinatorial Library Synthesis: A valuable reagent for generating diverse chemical libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	4-(Isocyanomethyl)Benzyl-Isocyanide
CAS No.	4973-73-3
Molecular Formula	C10H8N2
Molecular Weight	156.19 g/mol
Synonyms	1,4-Phenylenedimethyl diisocyanide; p-Xylylene diisocyanide; 1,4-Bis(isocyanomethyl)benzene; α,α'-Diisocyano-p-xylene; 4-(Isocyanomethyl)benzyl isocyanide; p-Bis(isocyanomethyl)benzene; p-Xylylenediisocyanide; p-Diisocyanomethylbenzene
EINECS	Contact for details

Quality Control

Our 4-(Isocyanomethyl)Benzyl-Isocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.