Description

Cyclobutanecarboxylic Acid, 3-Hydroxy-, Methyl Ester is a versatile chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its unique cyclobutane ring fused with a hydroxy ester functional group makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and fine chemical production.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing constrained cyclobutane rings.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the stereochemistry and ring strain influence biological activity.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Monomer: Investigated as a specialty monomer for producing polymers with unique thermal and mechanical properties derived from the cyclobutane structure.
• Fragrance and Flavor Chemistry: Potential intermediate for synthesizing musky or woody odorants due to its strained carbocyclic framework.
• Academic and R&D: Employed in methodological studies and total synthesis projects within university and corporate research laboratories.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Hydroxy-, Methyl Ester
CAS No.	4934-99-0
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	Methyl 3-Hydroxycyclobutanecarboxylate; 3-Hydroxycyclobutanecarboxylic Acid Methyl Ester; 3-Hydroxycyclobutane-1-carboxylic Acid Methyl Ester; Methyl 3-Hydroxycyclobutane-1-carboxylate; 3-Hydroxy-1-cyclobutanecarboxylic Acid Methyl Ester; (3-Hydroxycyclobutyl)carboxylic Acid Methyl Ester; Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester
EINECS	225-575-8

Quality Control

Our Cyclobutanecarboxylic Acid, 3-Hydroxy-, Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, which include data from techniques such as HPLC, GC, NMR, and chiral analysis. Our quality system is designed to meet the stringent requirements of cGMP for advanced intermediates and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Enantiomer Specific)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.