Description

5-Methyl-1,2,4-triazolo[4,3-a]pyridine-3-thiol is a versatile heterocyclic organic compound featuring a fused triazolopyridine core with a thiol functional group. This unique structure makes it a valuable pharmaceutical intermediate and key building block in medicinal chemistry for the synthesis of novel active ingredients. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Used in the research and development of advanced organic materials, including ligands for catalysis and components for electronic materials.
• Chemical Synthesis: Employed in organic synthesis as a versatile scaffold for constructing complex heterocyclic compounds in academic and industrial R&D.
• Bioconjugation & Probe Development: The reactive thiol group allows for use in bioconjugation chemistry and the creation of biochemical probes for diagnostic applications.

Basic Information

Item	Details
Product Name	5-Methyl-1,2,4-triazolo[4,3-a]pyridine-3-thiol
CAS No.	4926-22-1
Molecular Formula	C7H7N3S
Molecular Weight	165.22 g/mol
Synonyms	5-Methyl-[1,2,4]triazolo[4,3-a]pyridine-3-thiol; 3-Mercapto-5-methyl-[1,2,4]triazolo[4,3-a]pyridine; 5-Methyl-1,2,4-triazolo[4,3-a]pyridine-3-thione; 3H-[1,2,4]Triazolo[4,3-a]pyridine-3-thione, 5-methyl-; 4926-22-1; 5-Methyl-1,2,4-triazolopyridine-3-thiol
EINECS	Contact for details

Quality Control

Our 5-Methyl-1,2,4-triazolo[4,3-a]pyridine-3-thiol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after the original container is opened.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.