Description

Estra-1,3,5(10)-Triene-3,17Beta-Diol 3-[Bis(2-Chloroethyl)Carbamate] 17-(Dihydrogen Phosphate) is a chemically modified steroid derivative, specifically a nitrogen mustard carbamate ester of estradiol phosphate. This compound is of significant interest in pharmaceutical research and development due to its potential as a prodrug or targeted therapeutic agent. It is primarily utilized by advanced research institutions and pharmaceutical companies engaged in oncology and hormone-related drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor or active moiety in the development of novel chemotherapeutic agents and targeted cancer therapies.
• Oncology Research: Used in biochemical and pharmacological studies to investigate alkylating agent mechanisms, hormone receptor targeting, and prodrug activation pathways.
• Steroid Prodrug Development: Acts as a model compound for designing estrogen-linked prodrugs aimed at improving drug selectivity and reducing systemic toxicity.
• Bioconjugation Studies: Employed in research exploring the conjugation of cytotoxic nitrogen mustard groups to steroid carriers for targeted drug delivery systems.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	Estra-1,3,5(10)-Triene-3,17Beta-Diol 3-[Bis(2-Chloroethyl)Carbamate] 17-(Dihydrogen Phosphate)
CAS No.	4891-15-0
Molecular Formula	C23H30Cl2NO6P
Molecular Weight	518.36 g/mol
Synonyms	Estradiol 3-[Bis(2-chloroethyl)carbamate] 17-phosphate; Estradiol Mustard Carbamate Phosphate; 17β-Estradiol 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate); NSC 112259; Phosphoric acid, 2-[3-[[bis(2-chloroethyl)amino]carbonyl]oxy]estra-1,3,5(10)-trien-17β-yl] dihydrogen ester; Estradiol-3-N-mustard-17-phosphate
EINECS	Contact for details

Quality Control

Our Estra-1,3,5(10)-Triene-3,17Beta-Diol 3-[Bis(2-Chloroethyl)Carbamate] 17-(Dihydrogen Phosphate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We support development and cGMP-grade requirements for advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.