Description

α-Hydroxypyridine-4-Methanesulphonic Acid is a versatile organic acid derivative, also known as 2-Hydroxypyridine-4-sulfonic acid, valued for its unique sulfonic acid functional group on a pyridine scaffold. This compound is a critical building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals, agrochemicals, and specialty chemicals. It is essential for research and manufacturing processes requiring a water-soluble, acidic heterocyclic moiety.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where its heterocyclic structure contributes to biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for creating complexing agents, ligands for metal catalysis, and organocatalysts used in asymmetric synthesis.
• Dye and Pigment Manufacturing: Intermediate in the production of specialty dyes, pigments, and optical brighteners due to its ability to introduce sulfonic acid groups for solubility and color properties.
• Corrosion Inhibitor Formulation: Component in specialty chemical formulations designed to protect metals in industrial cooling and processing systems.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal and synthetic chemistry.

Basic Information

Product Name	α-Hydroxypyridine-4-Methanesulphonic Acid
CAS No.	4872-28-0
Molecular Formula	C6H7NO4S
Molecular Weight	189.19 g/mol
Synonyms	2-Hydroxypyridine-4-sulfonic Acid; 4-Pyridinesulfonic Acid, 2-hydroxy-; 2-Hydroxy-4-pyridinesulfonic Acid; 2-Pyridinol-4-sulfonic Acid; α-Hydroxypyridine-4-methanesulfonic Acid; 4-Sulfo-2-pyridinol; 2-Hydroxyisonicotinic acid sulfonic acid; 2-Hydroxypyridine-4-sulphonic Acid
EINECS	225-502-1

Quality Control

Our α-Hydroxypyridine-4-Methanesulphonic Acid is manufactured under a strict quality management system. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for sensitive pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in water, methanol; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.