Description

11β-Hydroxy-3α-(Trimethylsiloxy)-5β-Androstan-17-One is a high-purity synthetic steroid derivative, a key intermediate in the synthesis of complex pharmaceutical compounds. Its precise stereochemistry and functional groups make it a valuable building block for research and development in the pharmaceutical industry. This compound is primarily utilized by manufacturers and R&D laboratories specializing in steroid chemistry, hormone-related therapies, and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for steroidal drugs.
• Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and developing novel therapeutic agents.
• Hormone Analog Synthesis: Serves as a key starting material for the production of modified androstane derivatives with potential biological activity.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid-based pharmaceuticals.

Basic Information

Product Name	11β-Hydroxy-3α-(Trimethylsiloxy)-5β-Androstan-17-One
CAS No.	4867-16-7
Molecular Formula	C22H38O3Si
Molecular Weight	378.62 g/mol
Synonyms	11β-Hydroxy-3α-(trimethylsilyloxy)-5β-androstan-17-one; 3α-(Trimethylsiloxy)-11β-hydroxy-5β-androstan-17-one; 5β-Androstan-17-one, 11β-hydroxy-3α-(trimethylsiloxy)-; 11β-Hydroxy-3α-trimethylsilyloxy-5β-androstan-17-one; 3α-Trimethylsilyloxy-11β-hydroxy-5β-androstan-17-one; 11β-Hydroxy-3α-(trimethylsiloxy)-etioallocholan-17-one
EINECS	Contact for details

Quality Control

Our 11β-Hydroxy-3α-(Trimethylsiloxy)-5β-Androstan-17-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.