Description

n-[(Benzyloxy)Carbonyl]-L-Methionine Pentachlorophenyl Ester is a specialized, high-purity amino acid derivative used as a key building block in peptide synthesis. This compound matters for its role as an activated ester, facilitating efficient and selective coupling reactions under mild conditions to construct complex peptides and proteins. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on producing therapeutic peptides, biochemical probes, and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated amino acid derivative for the efficient, stepwise construction of peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: For the coupling of methionine residues in complex peptide sequences where standard coupling reagents may be less effective.
• Pharmaceutical Intermediate: In the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: For the site-specific modification of proteins, antibodies, or other biomolecules with methionine-containing tags or linkers.
• Biochemical Research: As a reagent for studying enzyme mechanisms, protein-protein interactions, and metabolic pathways involving methionine.
• Production of Custom Peptides: Used by CROs and CDMOs to manufacture bespoke peptides for clients in academia and industry.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Methionine Pentachlorophenyl Ester
CAS No.	4841-70-7
Molecular Formula	C20H18Cl5NO4S
Molecular Weight	539.60 g/mol
Synonyms	Z-L-Met-OPcp; Z-Met-OPcp; Cbz-L-Methionine Pentachlorophenyl Ester; N-Carbobenzoxy-L-methionine pentachlorophenyl ester; Benzyloxycarbonyl-L-methionine pentachlorophenyl ester; L-Methionine, N-[(phenylmethoxy)carbonyl]-, pentachlorophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-4-(methylthio)butanoic pentachlorophenyl ester; Z-Met-OPcp ester
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Methionine Pentachlorophenyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality commitment supports research and development requiring reliable, high-grade chemical building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under inert atmosphere when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Melting Point	Specific range provided on COA
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.