Description

2-Isocyanatopyridine is a versatile and highly reactive heterocyclic building block essential for advanced organic synthesis. Its primary value lies in its isocyanate functional group, which readily undergoes addition reactions with nucleophiles like amines and alcohols, making it a key precursor for the creation of ureas, carbamates, and other functionalized pyridine derivatives. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular scaffolds and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyridine-based pharmacophores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific pyridine-urea or carbamate structures.
• Polymer Modification: Serves as a reactive monomer or cross-linking agent for producing polyurethanes and other specialty polymers with enhanced properties.
• Ligand and Catalyst Development: Employed to create novel pyridine-containing ligands for metal complexes used in catalysis and material science.
• Chemical Biology Probes: Useful for labeling biomolecules or synthesizing activity-based probes for proteomics and diagnostic research.
• Organic Synthesis Reagent: A fundamental reagent for introducing the isocyanate functionality onto pyridine rings in multi-step synthetic routes.

Basic Information

Product Name	2-Isocyanatopyridine
CAS No.	4737-19-3
Molecular Formula	C6H4N2O
Molecular Weight	120.11 g/mol
Synonyms	2-Pyridyl isocyanate; Isocyanic acid, 2-pyridyl ester; Pyridine-2-isocyanate; 2-Pyridinyl isocyanate; 2-Isocyanato-pyridine; α-Pyridyl isocyanate; 2-PIC
EINECS	225-235-6

Quality Control

Our 2-Isocyanatopyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical properties is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and reactive nature, store in a cool (15-25°C), dry, and well-ventilated area, away from heat, open flames, and incompatible materials such as strong bases, alcohols, amines, and water. Use under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.