Description

2-Chloro-5-Nitropyridine is a versatile and high-value halogenated nitropyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a reactive chlorine substituent, makes it indispensable for constructing complex molecular architectures. This intermediate is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those with pyridine-based cores, such as kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the nitropyridine moiety contributes to biological activity.
• Material Science Research: Employed as a monomer or functionalization agent in the development of specialty polymers, ligands for catalysis, and organic electronic materials.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex heterocyclic dyes and pigments due to its reactive sites suitable for further coupling reactions.

Basic Information

Product Name	2-Chloro-5-Nitropyridine
CAS No.	4548-45-2
Molecular Formula	C5H3ClN2O2
Molecular Weight	158.54 g/mol
Synonyms	5-Nitro-2-chloropyridine; 2-Chloro-5-nitropyridine; 2-Chloro-5-nitro-pyridine; 5-Nitro-2-pyridinyl chloride; Pyridine, 2-chloro-5-nitro-; 4548-45-2; NSC 403697
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Nitropyridine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) documenting all critical parameters are available upon request, providing full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 99 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.