Description

Dimethyl 2,4:3,5-Di-o-Methylene-D-Glucarate is a high-purity, chemically protected derivative of D-glucaric acid, serving as a crucial chiral building block and synthetic intermediate. Its value lies in providing a rigid, locked conformation that is essential for stereoselective synthesis and the development of complex molecular architectures. This compound is particularly needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Used as a key starting material or advanced intermediate for the preparation of novel drug candidates, particularly those requiring specific stereochemistry.
• Asymmetric Catalyst and Ligand Precursor: Serves as a scaffold for developing new chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the synthesis of biologically active compounds with potential herbicidal or insecticidal properties.
• Carbohydrate Chemistry Research: A valuable tool for studying glycosidase inhibition and for the synthesis of complex sugars, glycomimetics, and C-glycosides.
• Polymer Science: Acts as a monomer or cross-linking agent for creating novel biodegradable or functional polymers with specific properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	Dimethyl 2,4:3,5-Di-o-Methylene-D-Glucarate
CAS No.	4539-77-9
Molecular Formula	C₁₀H₁₄O₈
Molecular Weight	262.21 g/mol
Synonyms	Dimethyl D-Glucarate 2,4:3,5-Dimethylene Acetal; D-Glucaric Acid, Dimethyl Ester, 2,4:3,5-Di-O-Methylene-; (2R,3S,4S,5R)-Dimethyl 2,4:3,5-Bis(methylenedioxy)hexanedioate; Dimethyl 2,4:3,5-Di-O-methylene-D-glucarate; 2,4:3,5-Di-O-Methylene-D-glucaric Acid Dimethyl Ester; Glucaric Acid, Dimethyl Ester, 2,4:3,5-Dimethylene Acetal; DIMETHYL 2,4:3,5-DI-O-METHYLENE-D-GLUCARATE
EINECS	Contact for details

Quality Control

Our Dimethyl 2,4:3,5-Di-o-Methylene-D-Glucarate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including chiral purity verification, to meet the exacting standards of synthetic chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.