Description

Chloroacetyl Isocyanate is a highly reactive bifunctional organic compound that serves as a versatile building block in advanced chemical synthesis. Its core value lies in enabling the efficient, single-step introduction of both a chloroacetyl group and an isocyanate functionality, streamlining the production of complex heterocycles and pharmacophores. This reagent is particularly critical for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of heterocyclic compounds, including oxazolidinones, quinazolinediones, and other nitrogen-containing scaffolds with potential biological activity.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where its reactive groups facilitate the creation of novel active molecules.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for the synthesis of specialty polyurethanes and polyureas with tailored properties.
• Peptide Modification: Employed to introduce specific functional handles or protective groups onto amino acids and peptides during research.
• Chemical Research & Development: A valuable tool for medicinal and process chemists exploring new synthetic routes and creating libraries of novel compounds for screening.

Basic Information

Product Name	Chloroacetyl Isocyanate
CAS No.	4461-30-7
Molecular Formula	C3H2ClNO2
Molecular Weight	119.50 g/mol
Synonyms	2-Chloroacetyl isocyanate; Chloroacetic acid isocyanate; Isocyanic acid, 2-chloroacetyl ester; NSC 163082; Chloracetyl isocyanate; α-Chloroacetyl isocyanate; 2-Chloroethanoyl isocyanate
EINECS	224-713-5

Quality Control

Our Chloroacetyl Isocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous demands of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as alcohols, amines, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.