Description

1-(Trimethylsilyl)-3-Chlorobenzene is a specialized organosilicon compound featuring both a trimethylsilyl protecting group and a reactive chloro substituent on an aromatic ring. This unique bifunctional structure makes it a valuable building block in advanced organic synthesis, particularly for the development of complex molecules where selective functionalization is required. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially where silicon is used as a temporary protecting group or to modulate lipophilicity.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides, fungicides, and insecticides that require chlorinated aromatic silane components.
• Material Science Precursor: Used in the development of novel silicon-based polymers, resins, and advanced organic electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki, Stille, or Kumada couplings, leveraging the chloro group for carbon-carbon bond formation.
• Ligand and Catalyst Development: Provides a functional handle for creating sophisticated ligands for catalysis or as a core structure in organometallic chemistry.
• Laboratory Reagent: Used in academic and industrial research for method development and exploring new synthetic pathways involving silyl-protected arenes.

Basic Information

Product Name	1-(Trimethylsilyl)-3-Chlorobenzene
CAS No.	4405-42-9
Molecular Formula	C9H13ClSi
Molecular Weight	184.74 g/mol
Synonyms	3-Chloro-1-(trimethylsilyl)benzene; m-Chlorophenyltrimethylsilane; (3-Chlorophenyl)trimethylsilane; Trimethyl(3-chlorophenyl)silane; 3-Chlorophenyltrimethylsilane; 3-(Trimethylsilyl)chlorobenzene; m-Chlorophenyltrimethylsilicon; Benzene, 1-chloro-3-(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-3-Chlorobenzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of research and fine chemical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.