Description

2-Trimethylsilyloxyethanol is a versatile organosilicon compound featuring a trimethylsilyl-protected hydroxyl group. This chemical is valued for its role as a key intermediate and protecting group reagent in sophisticated organic synthesis, particularly for sensitive alcohols. It is essential for manufacturers and R&D teams in the pharmaceutical, agrochemical, and specialty chemical sectors who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), where its silyl group protects alcohol functionalities during multi-step reactions.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that require selective protection and deprotection strategies.
• Polymer & Material Science: Serves as a monomer or modifying agent in the development of specialty silicones and functional polymers with tailored surface properties.
• Organic Synthesis Reagent: Employed as a trimethylsilyl (TMS) transfer agent for protecting hydroxyl groups in complex natural product and fine chemical synthesis.
• Cross-Coupling Reactions: Acts as a substrate or reagent in palladium-catalyzed and other metal-mediated coupling reactions to form carbon-carbon bonds.
• Derivatization Agent: Used in analytical chemistry to derivative alcohols for improved detection and analysis via gas chromatography (GC) or mass spectrometry (MS).

Basic Information

Product Name	2-Trimethylsilyloxyethanol
CAS No.	4403-13-8
Molecular Formula	C5H14O2Si
Molecular Weight	134.25 g/mol
Synonyms	2-[(Trimethylsilyl)oxy]ethanol; Ethanol, 2-(trimethylsilyloxy)-; 2-Hydroxyethyl trimethylsilyl ether; Trimethylsilyl 2-hydroxyethyl ether; 2-(Trimethylsiloxy)ethanol; TMS-ethanol; β-Trimethylsilyloxyethanol; (2-Hydroxyethoxy)trimethylsilane
EINECS	224-548-5

Quality Control

Our 2-Trimethylsilyloxyethanol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including gas chromatography (GC) and nuclear magnetic resonance (NMR) spectroscopy, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.415
Density (20°C)	0.88 - 0.92 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.