Description

2-(Chloromethyl)Pyridine CAS NO 4377-33-7 is a versatile and reactive heterocyclic building block, a chloromethyl derivative of pyridine. This compound is valued for its bifunctional reactivity, where the chloromethyl group acts as an electrophilic site for alkylation and the pyridine ring can coordinate to metals or act as a directing group. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require a high-purity intermediate for synthesizing complex molecules, including active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates, particularly those containing pyridine-based pharmacophores, such as antihistamines, antivirals, and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where it serves as a core structural component to enhance biological activity.
• Ligand and Catalyst Preparation: The pyridine nitrogen makes it a useful starting material for synthesizing chelating ligands in coordination chemistry and homogeneous catalysis.
• Chemical Research & Development: Employed in organic synthesis for constructing more complex heterocyclic systems and functionalized pyridine derivatives.
• Material Science: Can be utilized in the modification of polymer surfaces or the creation of functional monomers for specialty materials.

Basic Information

Product Name	2-(Chloromethyl)Pyridine
CAS No.	4377-33-7
Molecular Formula	C6H6ClN
Molecular Weight	127.57 g/mol
Synonyms	2-Picolyl Chloride; 2-Chloromethylpyridine; α-Chloro-2-picoline; (2-Pyridyl)methyl Chloride; 2-Pyridinemethanamine, N-chloro derivative; 2-Pyridylmethyl Chloride; 2-(Chloromethyl)pyridine Hydrochloride (salt form); 2-Picolylchloride
EINECS	224-479-5

Quality Control

Our 2-(Chloromethyl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.