Description

Epipodophyllotoxin is a key lignan-derived intermediate and a vital precursor in the synthesis of important chemotherapeutic agents. Its significance lies in its role as the core structural scaffold for producing podophyllotoxin derivatives, which are critical for modern oncology research and drug development. This high-purity compound is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on anticancer therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical starting material for the semi-synthesis of etoposide, teniposide, and other podophyllotoxin-derived anticancer drugs.
• Oncology Research: Serves as a reference standard and a key building block in medicinal chemistry programs aimed at developing novel topoisomerase II inhibitors.
• Biochemical Studies: Used in mechanistic studies to investigate cell cycle arrest, apoptosis induction, and the interaction with tubulin and topoisomerase enzymes.
• API Manufacturing: An essential raw material in the controlled, multi-step synthesis of complex therapeutic agents within GMP-compliant facilities.
• Academic & Discovery Chemistry: Fundamental compound for synthesizing new chemical entities (NCEs) and analogs to explore structure-activity relationships (SAR) in anticancer drug discovery.

Basic Information

Product Name	Epipodophyllotoxin
CAS No.	4375-07-9
Molecular Formula	C22H22O8
Molecular Weight	414.41 g/mol
Synonyms	4'-Demethylepipodophyllotoxin; (-)-4'-Demethylepipodophyllotoxin; NSC 334740; 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; Podophyllotoxin, 4'-demethyl-, epi-; Epipodophyllotoxin, 4'-demethyl-
EINECS	Contact for details

Quality Control

Our Epipodophyllotoxin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical synthesis. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.