Description

Podophyllotoxin is a potent aryltetralin lignan and a key pharmaceutical intermediate with significant biological activity. Its primary value lies in its role as the direct precursor for the semi-synthesis of important anticancer and antiviral drugs, including etoposide and teniposide. This high-purity compound is essential for manufacturers in the pharmaceutical, biotechnology, and advanced fine chemical sectors engaged in oncological and antiviral therapeutic development.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Critical starting material for the semi-synthetic production of chemotherapeutic agents etoposide, teniposide, and etopophos.
• Topical Antiviral Formulations: Used as the active component in prescription medications for the treatment of genital warts caused by human papillomavirus (HPV).
• Biochemical Research: Serves as a valuable reference standard and tool compound in cancer research, studying tubulin polymerization inhibition and cell cycle arrest.
• Natural Product Isolation & Purification: Used as a benchmark in the extraction and purification processes of podophyllotoxin from plant sources like Podophyllum species.
• Fine Chemical Intermediate: Employed in organic synthesis for creating novel derivatives with potential therapeutic applications.

Basic Information

Product Name	Podophyllotoxin
CAS No.	4354-76-1
Molecular Formula	C22H22O8
Molecular Weight	414.41 g/mol
Synonyms	Podofilox; Condylox; (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; NSC 24818; (-)-Podophyllotoxin; Podophyllotoxine; 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
EINECS	224-419-5

Quality Control

Our Podophyllotoxin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with in-house specifications that align with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.