Description

Trimethylsilyl Chlorosulfonate is a highly reactive organosilicon reagent primarily used as a powerful silylating and sulfonating agent. Its value lies in its ability to introduce the trimethylsilyl (TMS) group and the chlorosulfonyl group in a single step, facilitating complex synthetic transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for protecting sensitive functional groups and synthesizing sulfonamide derivatives.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of sulfonamide drugs and for protecting hydroxyl and amino groups during multi-step synthesis.
• Agrochemical Production: Used in the manufacture of sulfonylurea-based herbicides and other active ingredients requiring sulfonamide linkages.
• Polymer & Material Science: Employed as a surface modifying agent and in the synthesis of specialty polymers with sulfonate functionalities.
• Analytical Chemistry: Serves as a derivatization agent for gas chromatography (GC) to enhance the volatility and detectability of polar compounds.
• Fine Chemical Synthesis: Facilitates the production of complex organic molecules, including dyes, pigments, and flavor/fragrance compounds.
• Research & Development: A versatile building block in academic and industrial R&D for exploring new synthetic methodologies.

Basic Information

Item	Detail
Product Name	Trimethylsilyl Chlorosulfonate
CAS No.	4353-77-9
Molecular Formula	C3H9ClO3SSi
Molecular Weight	188.68 g/mol
Synonyms	Chlorosulfonic Acid Trimethylsilyl Ester; Trimethylsilyl Chlorosulfate; (Trimethylsilyl) Chlorosulfonate; TMS Chlorosulfonate; Trimethylsilyl Sulfurochloridate; NSC 93766; Chlorosulfonyloxytrimethylsilane
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Chlorosulfonate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assay (GC/HPLC), identity confirmation (IR, NMR), and impurity profiling, to ensure it meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.