Description

Dacarbazine CAS NO 4342-03-4 is a synthetic antineoplastic agent belonging to the class of alkylating agents. This compound is critically important as a key active pharmaceutical ingredient (API) in the formulation of chemotherapeutic drugs. It is primarily required by pharmaceutical manufacturers and research institutions engaged in oncology drug development and production for the treatment of various cancers, including metastatic malignant melanoma and Hodgkin's lymphoma.

Application

• Oncological Pharmaceutical Manufacturing: Primary use as the active pharmaceutical ingredient (API) in injectable chemotherapy formulations.
• Hodgkin's Lymphoma Treatment: A component of the ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) chemotherapy regimen.
• Metastatic Malignant Melanoma Therapy: Used as a single agent or in combination protocols for advanced melanoma.
• Clinical Research & Drug Development: Serves as a reference standard and investigational compound in preclinical and clinical oncology studies.
• Pharmaceutical Compounding: Used by specialized compounding pharmacies for tailored patient-specific chemotherapy doses.
• Biomedical Research: Utilized in laboratory studies to investigate mechanisms of alkylation, DNA cross-linking, and cancer cell apoptosis.

Basic Information

Product Name	Dacarbazine
CAS No.	4342-03-4
Molecular Formula	C6H10N6O
Molecular Weight	182.18 g/mol
Synonyms	DTIC; DIC; Imidazole Carboxamide; 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; WR-139007; NSC-45388; DTIC-Dome; Dacarbazina; Dacarbazin
EINECS	224-394-8

Quality Control

Our Dacarbazine is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, in compliance with current pharmacopeial standards (e.g., USP, EP). A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the container must be kept tightly sealed in a dry environment and opened only under appropriate low-light conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to pale yellow or light tan crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.