Description

1H-1,2,3-Triazole-1-Acetic Acid Ethyl Ester is a versatile heterocyclic building block and ester derivative, essential for constructing complex molecular architectures in advanced organic synthesis. Its core value lies in its bifunctional nature, featuring both a reactive triazole ring and an ester group, which facilitates its use as a key intermediate in the development of pharmaceuticals and agrochemicals. This compound is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to incorporate the 1,2,3-triazole pharmacophore into their target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing the 1,2,3-triazole moiety, which is known for its metabolic stability and ability to participate in hydrogen bonding.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and insecticides, where the triazole ring contributes to biological activity and target binding.
• Click Chemistry Reagent: Serves as an azide precursor or a component in Huisgen 1,3-dipolar cycloaddition reactions for the efficient, modular construction of complex molecules in drug discovery and material science.
• Ligand and Catalyst Development: Employed in the preparation of nitrogen-containing ligands for transition metal catalysis, useful in various cross-coupling and polymerization reactions.
• Polymer and Material Science: Acts as a monomer or functionalizing agent for creating polymers with specific thermal, mechanical, or biological properties.
• Bioconjugation and Probe Synthesis: Utilized in the labeling of biomolecules (proteins, nucleic acids) for diagnostic assays, imaging, and biochemical research.

Basic Information

Product Name	1H-1,2,3-Triazole-1-Acetic Acid Ethyl Ester
CAS No.	4314-21-0
Molecular Formula	C6H9N3O2
Molecular Weight	155.16 g/mol
Synonyms	Ethyl 1H-1,2,3-triazole-1-acetate; 1H-1,2,3-Triazol-1-yl-acetic acid ethyl ester; 1-(Carboxymethyl)-1H-1,2,3-triazole ethyl ester; Ethyl (1H-1,2,3-triazol-1-yl)acetate; 1H-1,2,3-Triazole-1-acetic acid, ethyl ester; NSC 163044; 1-Triazolylacetic acid ethyl ester
EINECS	224-342-9

Quality Control

Our 1H-1,2,3-Triazole-1-Acetic Acid Ethyl Ester is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to meet the exacting standards of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.