Description

Dacarbazine is an alkylating antineoplastic agent belonging to the class of triazenes. This compound is a critical active pharmaceutical ingredient (API) valued for its role in chemotherapy regimens. It is primarily required by pharmaceutical manufacturers and research institutions developing and producing oncology treatments. Our supply ensures high purity and reliable consistency for demanding pharmaceutical applications.

Application

• Oncological Pharmaceutical Manufacturing: As the active ingredient in injectable chemotherapy drugs for the treatment of metastatic malignant melanoma and Hodgkin's lymphoma.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for investigating new cancer treatment protocols and combination therapies.
• Reference Standard Production: Serves as a high-purity chemical reference standard for quality control laboratories in pharmacopeial testing (e.g., USP, EP).
• Antineoplastic Agent Synthesis: Acts as a key intermediate or precursor in the synthesis of related triazene-based chemotherapeutic compounds.

Basic Information

Product Name	Dacarbazine
CAS No.	4243-04-3
Molecular Formula	C6H10N6O
Molecular Weight	182.18 g/mol
Synonyms	5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; DTIC; DIC; Imidazole Carboxamide; WR-139007; NSC-45388; DTIC-Dome; Dacarbazinum
EINECS	224-204-8

Quality Control

Our Dacarbazine is manufactured and tested under strict quality systems. We provide material that meets high-purity standards suitable for pharmaceutical applications, with testing aligned with major pharmacopeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to ivory-colored powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 2.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.