Description

tert-Butyl (R)-2-Hydroxy-3-Methylbutyrate is a high-value chiral building block and intermediate in organic synthesis. Its primary significance lies in its role as a key precursor for the synthesis of complex pharmaceutical molecules, particularly those requiring stereochemical control. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of protease inhibitors, antiviral drugs, and other therapeutics.
• Asymmetric Synthesis: Used as a starting material or auxiliary in asymmetric synthesis to introduce the (R)-2-hydroxy-3-methylbutyrate moiety into target molecules with high enantiomeric excess.
• Agrochemical Synthesis: Serves as a building block for the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Flavor and Fragrance Industry: Potential intermediate for the synthesis of complex, naturally-derived flavor and aroma compounds.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and catalysis research within university and corporate laboratories.
• Peptide Mimetics: Used in the construction of peptidomimetics and other bioactive compounds designed to mimic natural peptide structures.

Basic Information

Item	Details
Product Name	tert-Butyl (R)-2-Hydroxy-3-Methylbutyrate
CAS No.	4216-96-0
Molecular Formula	C9H18O3
Molecular Weight	174.24 g/mol
Synonyms	(R)-2-Hydroxy-3-methylbutyric acid tert-butyl ester; (R)-tert-Butyl 2-hydroxy-3-methylbutanoate; (R)-HMB-OtBu; (R)-2-Hydroxy-3-methylbutyric acid 1,1-dimethylethyl ester; (R)-3-Methyl-2-hydroxybutyric acid tert-butyl ester; tert-Butyl (2R)-2-hydroxy-3-methylbutyrate; (R)-O-t-Butyl 2-hydroxy-3-methylbutyrate
EINECS	224-155-9

Quality Control

Our tert-Butyl (R)-2-Hydroxy-3-Methylbutyrate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.