Description

3,4-Didehydroretinoic Acid is a biologically active metabolite of vitamin A, playing a crucial role in cellular differentiation and proliferation. This high-purity compound is essential for advanced research and development in life sciences, offering a critical tool for studying retinoid signaling pathways. It is primarily sought by pharmaceutical R&D teams, academic researchers, and manufacturers of high-value biochemicals for applications in oncology, dermatology, and metabolic disease research.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel retinoid-based therapies.
• Biochemical & Cell Biology Studies: Used as a potent ligand to investigate the mechanisms of nuclear receptors (RARs/RXRs) and their role in gene expression, cell growth, and apoptosis.
• Dermatological Research: Employed in studies focused on skin cell regeneration, acne treatment mechanisms, and the development of cosmeceuticals targeting photoaging and hyperpigmentation.
• Oncology Research: Investigated for its potential differentiating effects on certain cancer cell lines, contributing to the study of chemoprevention and differentiation therapy.
• Metabolic Disorder Studies: Applied in research exploring the link between retinoid metabolism, insulin sensitivity, and lipid homeostasis.
• Analytical Standard: Utilized as a high-purity certified reference material (CRM) for method development, validation, and quality control in analytical laboratories.

Basic Information

Product Name	3,4-Didehydroretinoic Acid
CAS No.	4159-20-0
Molecular Formula	C₂₀H₂₆O₂
Molecular Weight	298.42 g/mol
Synonyms	Vitamin A2 Acid; all-trans-3,4-Didehydroretinoic Acid; 3,4-DDRA; Retinoic Acid A2; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; Tretinoin A2; Ro 13-6307
EINECS	224-001-9

Quality Control

Our 3,4-Didehydroretinoic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.