Description

1,2:3,4-Di-o-Isopropylidene-6-o-Mesyl-α-D-Galactopyranose is a key protected monosaccharide derivative, specifically a mesylate ester of a galactose analog, widely used as a versatile chiral building block in organic synthesis. Its primary value lies in its reactive mesylate group, which facilitates further functionalization and chain elongation, making it indispensable for constructing complex carbohydrate and nucleoside structures. This high-purity intermediate is critically needed by pharmaceutical R&D teams and fine chemical manufacturers for the development of antiviral drugs, novel glycosidase inhibitors, and advanced glycoconjugates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of nucleoside analogs and antiviral agents, such as experimental treatments for viral infections.
• Carbohydrate Chemistry: Serves as a protected galactose derivative for the stepwise construction of complex oligosaccharides, glycopeptides, and glycolipids.
• Glycoconjugate Research: Used in the development of vaccine adjuvants, targeted drug delivery systems, and diagnostic probes that rely on specific carbohydrate-protein interactions.
• Chiral Pool Synthesis: Provides a readily available source of chirality for the asymmetric synthesis of non-carbohydrate bioactive molecules.
• Chemical Biology Probes: Acts as a starting material for synthesizing activity-based probes to study glycosidase enzymes and carbohydrate-processing pathways.
• Process Development: Employed in scale-up and optimization studies for the commercial production of carbohydrate-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1,2:3,4-Di-o-Isopropylidene-6-o-Mesyl-α-D-Galactopyranose
CAS No.	4148-55-4
Molecular Formula	C13H22O8S
Molecular Weight	338.38 g/mol
Synonyms	6-O-Mesyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose; 1,2:3,4-Di-O-isopropylidene-6-O-(methylsulfonyl)-α-D-galactopyranose; 6-O-(Methanesulfonyl)-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose; D-Galactose, 6-(methylsulfonate), 1,2:3,4-diisopropylidene deriv.; 1,2:3,4-Di-O-isopropylidene-α-D-galactopyranose 6-methanesulfonate; 4148-55-4; α-D-Galactopyranose, 1,2:3,4-di-O-(1-methylethylidene)-6-(methylsulfonate)
EINECS	223-977-2

Quality Control

Our 1,2:3,4-Di-o-Isopropylidene-6-o-Mesyl-α-D-Galactopyranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and reactivity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation [α]²⁰D	-40° to -44° (c=1 in CHCl₃)
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.