Description

p-Toluenesulfonyl Isocyanate (TosMIC) is a versatile and highly reactive organic building block, primarily valued for its role as a key reagent in heterocyclic synthesis. Its importance lies in its ability to act as a one-carbon synthon, facilitating the efficient construction of complex molecular architectures like imidazoles, oxazoles, and other nitrogen-containing heterocycles. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and advanced intermediates.

Application

• Key reagent in the synthesis of imidazoles via the van Leusen reaction.
• Building block for the preparation of oxazoles and other five-membered heterocycles.
• Intermediate in the production of pharmaceutical active ingredients and agrochemicals.
• Used in the synthesis of functionalized isocyanates and sulfonyl derivatives.
• Reagent for the introduction of the tosylmethyl isocyanide functional group.
• Employed in material science for creating specialized polymers and ligands.

Basic Information

Product Name	p-Toluenesulfonyl Isocyanate
CAS No.	4083-64-1
Molecular Formula	C8H7NO3S
Molecular Weight	197.21 g/mol
Synonyms	Tosylmethyl isocyanide (TosMIC); 4-Methylbenzenesulfonyl isocyanate; p-Tolylsulfonyl isocyanate; Tosyl isocyanate; Toluenesulfonyl isocyanide; 4-Toluenesulfonyl isocyanate; (Isocyanatosulfonyl)toluene
EINECS	223-809-8

Quality Control

Our p-Toluenesulfonyl Isocyanate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Melting Point	58 - 62 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.