Description

Ethyl (Trimethylsilyl)Acetate is a versatile organosilicon reagent featuring a silyl-protected acetate ester group. This compound is valued for its role as a synthetic building block, enabling the introduction of the trimethylsilyl group and facilitating specific transformations in organic synthesis. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing protected carboxylate functionalities.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where silicon-containing moieties are required.
• Organic Synthesis Reagent: Acts as a trimethylsilylating agent and a protected acetate anion equivalent in various carbon-carbon bond-forming reactions.
• Polymer & Material Science: Employed in the modification of polymers and the creation of silicon-based hybrid materials with tailored properties.
• Cross-Coupling Reactions: Utilized as a substrate in palladium-catalyzed cross-coupling reactions to construct complex organic molecules.
• Academic & Industrial R&D: A valuable tool for method development and exploratory chemistry in both academic and corporate research laboratories.

Basic Information

Product Name	Ethyl (Trimethylsilyl)Acetate
CAS No.	4071-88-9
Molecular Formula	C7H16O2Si
Molecular Weight	160.29 g/mol
Synonyms	Ethyl 2-(Trimethylsilyl)acetate; Acetic acid, 2-(trimethylsilyl)-, ethyl ester; 2-(Trimethylsilyl)acetic acid ethyl ester; Ethyl trimethylsilylacetate; (Trimethylsilyl)acetic acid ethyl ester; TMS-acetic acid ethyl ester; Ethyl (trimethylsilyl)ethanoate
EINECS	223-783-6

Quality Control

Our Ethyl (Trimethylsilyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can compromise product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.