Description

[R-(R*,R*)]-2-(2,2-Dichloroacetamido)-3-Hydroxy-3-(p-Nitrophenyl)Ethyl Benzoate is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its complex molecular structure, featuring a dichloroacetamido group and a p-nitrophenyl moiety, makes it a valuable building block for the synthesis of specialized active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting specific biological pathways.
• Research Chemical: Used in academic and industrial R&D laboratories for method development, structure-activity relationship (SAR) studies, and exploring new synthetic routes.
• API Synthesis: Serves as a critical precursor in the manufacture of high-value, optically active active pharmaceutical ingredients where the defined stereochemistry is crucial for efficacy.
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying enzyme mechanisms or receptor interactions due to its functionalized structure.
• Process Chemistry Development: Employed by process chemists to scale up and optimize synthetic pathways for potential commercial drug production.

Basic Information

Product Name	[R-(R*,R*)]-2-(2,2-Dichloroacetamido)-3-Hydroxy-3-(p-Nitrophenyl)Ethyl Benzoate
CAS No.	492-79-5
Molecular Formula	C17H14Cl2N2O6
Molecular Weight	413.21 g/mol
Synonyms	Benzoic acid, 2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester, (R*,R*)-(-)-; (2R,3R)-2-(2,2-Dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propyl benzoate; Chloramphenicol Monobenzoate; Chloramphenicol α-Monobenzoate; Chloramphenicol 3-Monobenzoate; D-(-)-Three-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol 3-Monobenzoate; D-(-)-Three-Chloramphenicol α-Monobenzoate
EINECS	207-762-8

Quality Control

Our [R-(R*,R*)]-2-(2,2-Dichloroacetamido)-3-Hydroxy-3-(p-Nitrophenyl)Ethyl Benzoate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While specific pharmacopeial monographs may not apply directly, our quality standards are aligned with the principles of ICH guidelines for impurities and analytical validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.