Description

Pamaquine is an 8-aminoquinoline derivative with significant historical and pharmacological importance. This compound is valued for its potent antimalarial properties, particularly against the dormant liver stages (hypnozoites) of certain *Plasmodium* parasites. It serves as a critical reference standard and active pharmaceutical ingredient (API) for research and development in parasitology and medicinal chemistry. Industries requiring this high-purity chemical include pharmaceutical R&D, analytical testing laboratories, and academic institutions focused on tropical disease research.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and assay development in pharmacopeial testing.
• Antimalarial Drug Research: Serves as a key intermediate and biological probe in the development of novel 8-aminoquinoline-based therapeutics.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the compound's behavior in biological systems.
• Analytical Method Development: Utilized to develop and validate HPLC, LC-MS, and other chromatographic methods for impurity profiling.
• Biochemical Assays: Acts as a tool compound in enzymatic and cellular assays to study mechanisms of action against parasitic targets.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in medicinal chemistry and parasitology.

Basic Information

Product Name	Pamaquine
CAS No.	491-92-9
Molecular Formula	C19H29N3O
Molecular Weight	315.45 g/mol
Synonyms	Pamaquine; Plasmoquine; Aminoquin; 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline; Gametocidum; Beprochine; Chinoplasmon; Praequine; SN 971
EINECS	207-745-4

Quality Control

Our Pamaquine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets high-grade standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.