Description

Premarin CAS NO 481-97-0 is a complex mixture of conjugated estrogens derived from natural sources, primarily used in pharmaceutical formulations. This product is critical for hormone replacement therapy (HRT) to manage menopausal symptoms and prevent osteoporosis in postmenopausal women. It is essential for pharmaceutical manufacturers and research institutions developing treatments for estrogen deficiency and related conditions.

Application

• Hormone Replacement Therapy (HRT): Primary active pharmaceutical ingredient (API) in medications for treating menopausal symptoms such as hot flashes, night sweats, and vaginal atrophy.
• Osteoporosis Prevention: Key component in therapeutic regimens to prevent bone density loss and reduce fracture risk in postmenopausal women.
• Pharmaceutical Research & Development: Used as a reference standard and active material in preclinical and clinical studies related to endocrinology and women's health.
• Vaginal Cream Formulations: Incorporated into topical preparations for the treatment of atrophic vaginitis and vulvar atrophy.
• Combination Drug Products: Formulated with progestogens in combined HRT products to provide a balanced hormonal effect and protect the endometrium.

Basic Information

Product Name	Premarin
CAS No.	481-97-0
Molecular Formula	Mixture
Molecular Weight	N/A (Conjugated Estrogen Mixture)
Synonyms	Conjugated Estrogens; Equine Conjugated Estrogens; Estrogens, Conjugated; Premarin (Brand Name); C.E.S.; CE; Conjugated Oestrogens; Estratab; Menest; Ogen
EINECS	207-580-1

Quality Control

Our Premarin is manufactured and tested to meet stringent pharmaceutical standards. Quality is assured through a comprehensive analytical program including chromatographic purity profiling and biological activity testing. We provide full traceability and Certificates of Analysis (COA) for each batch, ensuring compliance with relevant pharmacopeial guidelines (e.g., USP monographs for Conjugated Estrogens).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Description	Light yellow to yellow amorphous powder
Identification (HPLC)	Conforms to Standard
Assay (Total Conjugated Estrogens)	90.0% - 110.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Microbial Limits	Meets USP <61> and <62>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.