Description

(1R)-1,4Aα,5,6,7,7Aα-Hexahydro-1-Hydroxy-7α-Methyl-5-Oxocyclopenta[C]Pyran-4-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the prostaglandin and steroid analog pathways. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of prostaglandin analogs and related bioactive molecules.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing complex, stereochemically defined cyclopentane and pyran ring systems.
• Fine Chemical Production: Serves as a precursor for manufacturing specialized chemicals with high purity requirements.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	(1R)-1,4Aα,5,6,7,7Aα-Hexahydro-1-Hydroxy-7α-Methyl-5-Oxocyclopenta[C]Pyran-4-Carboxylic Acid Methyl Ester
CAS No.	479-48-1
Molecular Formula	C11H14O5
Molecular Weight	226.23 g/mol
Synonyms	Methyl (1R,4aS,7aR)-1-Hydroxy-7a-methyl-5-oxo-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate; 7a-Methyl-2,3,5,6,7,7a-hexahydro-1-hydroxy-5-oxocyclopenta[c]pyran-4-carboxylic acid methyl ester; Prostaglandin Intermediate; Corey Lactone Derivative; (1R,4aS,7aR)-1-Hydroxy-7a-methyl-5-oxo-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester
EINECS	207-543-1

Quality Control

Our (1R)-1,4Aα,5,6,7,7Aα-Hexahydro-1-Hydroxy-7α-Methyl-5-Oxocyclopenta[C]Pyran-4-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.