Description

(2R,3R,E)-5-Ethylidene-2-Hydroxy-2,3-Dimethylhexanedioic Acid is a high-purity, stereochemically defined organic acid building block. This compound is valued for its unique chiral structure, which makes it a critical intermediate in the synthesis of complex pharmaceutical molecules and advanced fine chemicals. It is primarily sought after by research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides.
• Catalyst Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the manufacture of complex, high-value specialty chemicals requiring specific stereochemistry.
• Academic & Industrial Research: A valuable tool for chemical research in synthetic methodology and stereochemistry studies.
• Bioconjugate Chemistry: Potential use in creating labeled compounds or probes for biochemical research due to its functional handles.

Basic Information

Product Name	(2R,3R,E)-5-Ethylidene-2-Hydroxy-2,3-Dimethylhexanedioic Acid
CAS No.	469-45-4
Molecular Formula	C10H16O5
Molecular Weight	216.23 g/mol
Synonyms	(2R,3R,E)-5-Ethylidene-2,3-Dimethyl-2-hydroxyhexanedioic Acid; (E)-(2R,3R)-5-Ethylidene-2-hydroxy-2,3-dimethylpentanedioic Acid; 2-Hydroxy-2,3-dimethyl-5-ethylidenehexanedioic Acid; (2R,3R)-5-Ethylidene-2-hydroxy-2,3-dimethylhexanedioic Acid; NSC 163022; A chiral derivative of glutaric acid.
EINECS	Contact for details

Quality Control

Every batch of (2R,3R,E)-5-Ethylidene-2-Hydroxy-2,3-Dimethylhexanedioic Acid is produced and tested under strict quality management systems. We guarantee high chiral purity and chemical identity through advanced analytical techniques including chiral HPLC and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to ensure it meets your precise research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its acidic nature, keep away from strong bases, oxidizing agents, and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.