Description

2-Chloro-2,2-Difluoroethanol is a versatile fluorinated alcohol building block, essential for introducing the difluoroethanol moiety into complex molecules. Its primary value lies in its bifunctional reactivity, serving as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). This compound is particularly needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, including antiviral and anticancer agents, where the difluoro group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to manufacture novel herbicides and pesticides, leveraging the fluorine atoms to improve efficacy and environmental profile.
• Polymer & Material Science: Serves as a monomer or modifier for producing specialty fluoropolymers with unique surface properties, chemical resistance, and thermal stability.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated liquid crystals and dielectric fluids for advanced display technologies and electronics.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution and esterification reactions to introduce the -CH2CF2Cl or derived functional groups.
• Solvent & Reaction Medium: Acts as a polar, fluorinated solvent for specialized chemical reactions and extraction processes.

Basic Information

Item	Details
Product Name	2-Chloro-2,2-Difluoroethanol
CAS No.	464-00-6
Molecular Formula	C2H3ClF2O
Molecular Weight	114.49 g/mol
Synonyms	2,2-Difluoro-2-chloroethanol; 2-Chloro-1,1-difluoroethanol; 1,1-Difluoro-2-chloroethanol; Chlorodifluoroethanol; α-Chloro-α,α-difluoroethanol; 2-Chloro-2,2-difluoroethan-1-ol; Ethanol, 2-chloro-2,2-difluoro-; NSC 60545
EINECS	207-353-6

Quality Control

Our 2-Chloro-2,2-Difluoroethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.40 - 1.45 g/mL
Refractive Index (n20D)	1.360 - 1.370

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.