Description

Methyl 2-Fluoroisonicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of both fluorine and an ester functional group onto the pyridine ring, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in catalysis and material science.
• Fluorinated Liquid Crystal Research: Employed in the development of novel fluorinated components for electronic display materials.
• Chemical Biology Probes: Utilized to create fluorinated analogs of bioactive molecules for mechanistic and metabolic studies.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring specific fluoropyridine architectures.

Basic Information

Product Name	Methyl 2-Fluoroisonicotinate
CAS No.	455-69-6
Molecular Formula	C7H6FNO2
Molecular Weight	155.13 g/mol
Synonyms	2-Fluoro-4-pyridinecarboxylic acid methyl ester; Methyl 2-fluoro-4-pyridinecarboxylate; 2-Fluoropyridine-4-carboxylic acid methyl ester; 4-(Methoxycarbonyl)-2-fluoropyridine; 2-Fluoroisonicotinic acid methyl ester; Methyl 2-fluoroisonicotinate; 455-69-6; 2-Fluoro-isonicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-Fluoroisonicotinate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the precise requirements of research and production applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by IR and NMR), and levels of specific impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.